Replication-selective Adenoviral Vector for Head and Neck Cancer
نویسندگان
چکیده
منابع مشابه
A replication-selective adenoviral vector for head and neck cancers.
OBJECTIVE To test the oncolytic activity of cyclo-oxygenase 2 (COX-2) promoter-based conditional replication-selective adenovirus vector for squamous cell carcinoma cells of the head and neck. DESIGN In vitro study. SUBJECTS None. INTERVENTIONS A conditional replication-selective adenovirus vector in which the expression of E1a, required for viral replication, is controlled by the COX-2 p...
متن کاملSelective gene delivery to head and neck cancer cells via an integrin targeted adenoviral vector.
In vivo cancer gene therapy approaches for squamous cell carcinoma of the head and neck (SCCHN) based on adenoviral vector-mediated gene delivery have been limited by the suboptimal efficacy of gene transfer to tumor cells. We hypothesized that this issue was due to deficiency of the primary adenoviral receptor, the coxsackie-adenovirus receptor (CAR), on the tumor targets. Studies of CAR level...
متن کاملCyclooxygenase 2 promoter-based replication-selective adenoviral vector for hypopharyngeal cancer.
OBJECTIVE To explore the potential clinical application of the oncolytic activity of cyclooxygenase 2 (COX-2) promoter-based, conditional, replication-selective adenovirus vector for hypopharyngeal squamous cell carcinoma. DESIGN In vivo study and retrospective study. SETTING Kobe University Hospital, Kobe, Japan. SUBJECTS Expression of COX-2 in hypopharyngeal cancers treated at Kobe Univ...
متن کاملOropharyngeal candidiasis and resistance to antifungal drugs in patients receiving radiation for head and neck cancer
BACKGROUND: Oropharyngeal candidiasis is a common infection in patient receiving radiotherapy for head and neck cancer. Accurate and rapid identification of candida species is very important in clinical laboratory, because the incidence of candidiasis continues to rise after radiotherapy. The genus Candida has about 154 species that show different level of resistance to antifungal drugs and hav...
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Quality of life in head and neck cancer patients
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ژورنال
عنوان ژورنال: Koutou (THE LARYNX JAPAN)
سال: 2005
ISSN: 0915-6127
DOI: 10.5426/larynx1989.17.2_89